Role of regulatory T cell populations in controlling graft vs host disease
نویسندگان
چکیده
منابع مشابه
Role of STAT3 in regulatory T lymphocyte plasticity during acute graft-vs.-host-disease
Regulatory T (Treg) lymphocytes are important mediators of the allogeneic immune response, although the mechanisms by which they are controlled are not fully understood. Studies conducted in mice, including a recent article in Immunity by Laurence et al., have shown that STAT3 is an important factor involved in the instability of natural Treg (nTreg) lymphocytes and the generation of induced Tr...
متن کاملThe Role of Regulatory T Cells in the Biology of Graft Versus Host Disease
Graft versus host disease (GVHD) is the major complication of allogeneic hematopoietic stem cell transplantation. GVHD is characterized by an imbalance between the effector and regulatory arms of the immune system which results in the over production of inflammatory cytokines. Moreover, there is a persistent reduction in the number of regulatory T (Treg) cells which limits the ability of the im...
متن کاملAnti-ASGM1, NK cell, activated T cell, and graft-vs-host disease.
To the Editor: In 1978, Korngold et al demonstrated that removal of "all mature" T lymphocytes by anti-Thy-1.2 and complement was very effective in preventing the development of significant graft-vs-host disease (GVHD) in mice [1]. However, implementation of this strategy in patients using OKT3 failed to achieve similar impressive results [2]. Having learned of the work of Lopez who demonstrate...
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FoxP3+ regulatory T cells (Tregs) are a subset of CD4+ T cells that can suppress proliferation and effector functions of T cells, B cells, NK cells, and antigen-presenting cells. Treg deficiency causes dramatic immunologic disease in both animal models and humans. As they are capable to suppress the function and the proliferation of conventional CD4+ and CD8+ T cells, Treg-based cell therapies ...
متن کاملGraft-vs-host disease following allogeneic hematopoietic cell transplantation.
BACKGROUND Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy with proven efficacy in the management of hematologic malignancies. However, it is complicated by the syndromes of acute and chronic graft-vs-host disease (GVHD). METHODS A narrative review is provided to summarize major biologic insights into the pathogenesis of these immune-mediated disorders, a...
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ژورنال
عنوان ژورنال: Best Practice & Research Clinical Haematology
سال: 2011
ISSN: 1521-6926
DOI: 10.1016/j.beha.2011.05.006